{
 "as_of": "2026-11-08",
 "cmr": "us-cm-kg/NASDAQ/UPB",
 "fence": "The page is the record's research on the issuer — no analyst, no rating, no view.",
 "markdown": "The page is the record's research on the issuer — no analyst, no rating, no view.\n\n# Upstream Bio, Inc. (NASDAQ: UPB) — research page\n\nAs of 2026-11-08 · us-cm-kg · record version 1\n\n## Identity and listing\n\nThe issuer is Upstream Bio, Inc., listed on NASDAQ under ticker UPB, with ISIN US91678A1079; its LEI is not on the record, which holds no GLEIF record with the exact legal name in jurisdiction US-DE. Its security type is Corporate, its segment is not on the record, its sector is 2834 Pharmaceutical Preparations, and its jurisdiction is United States, Delaware. The issuer is listed and not halted.\n\n## The disclosure read\n\nThe record holds 49 filings in the window 2025-11-08 to 2026-11-08, across 18 filing days. Of these, 26 are directors' dealings, 9 are regulatory filings, 7 are results, 3 are AGM/EGM notices, 3 are corporate news, and 1 is a prospectus. The median gap between filing days is 20 days. The latest filing is dated 2026-11-06 and is a regulatory filing, 2 days before the record date of 2026-11-08. On NASDAQ the median cadence gap is 6.0 days, the median filings count is 52, and the median latency is 5.0 days, across 4359 issuers. In the sector 2834 Pharmaceutical Preparations, the median cadence gap is 6.0 days, the median filings count is 63.0, and the median latency is 4.0 days, across 526 issuers.\n\n## Auditor\n\nThe auditor of record is not on the record, which carries no dei:AuditorName tag on the latest annual report cover; the auditor's location is not on the record. The record holds no auditor changes.\n\n## Events and halts\n\nThe record holds no listing, delisting or name change lines. The domicile change is not on the record, as EDGAR states no dated change of state of incorporation on a filing line. The segment move is not on the record, as the exchanges' tier transfers are not EDGAR filings. The halt flag is listed, not halted.\n\n## Orderability\n\nThe outcome is not determinable, because the chapter's orderability section carries no client categories and so the outcome cannot name its client category. The rule version is acm-68000/us/reasonable-basis-suitability-finra-rule-2111/r1, and the chapter is as of 2026-11-04.\n\n## Coverage\n\nNo research houses were found on the issuer's own investor-relations page; the count is 0.\n\n## Open research\n\nNo openly published research notes were found on the record; the count is 0.\n\n## Licensed\n\nLicensed research: none loaded. A licensed row is served only to an agent whose firm holds that licence (licensor, entitlement). No licensed row is loaded.\n\n## As-of depth\n\nThe issuer's years sealed are 2024, 2025 and 2026. The market's earliest sealed date is 2021-01-04. The live record began on 2026-09-12.\n\n## Sources\n\n7 source pages are named on this page; every value above carries its own source page and read date in the numbers.\n\n- https://www.sec.gov/files/company_tickers_exchange.json (identity.exchange)\n- https://www.sec.gov/data-research/sec-markets-data/fails-deliver-data (identity.isin)\n- https://data.sec.gov/submissions/CIK0002022626.json (identity.jurisdiction)\n- https://mcp.us-cm-kg.ai/events/NASDAQ/UPB (the disclosure lines)\n- https://www.nasdaqtrader.com/rss.aspx?feed=tradehalts (the halt flag)\n- https://mcp.us-cm-kg.ai/book/aio.json (the orderability chapter)\n- https://mcp.us-cm-kg.ai/record/NASDAQ/UPB (the record)\n",
 "market": "US",
 "node": "us-cm-kg",
 "numbers": {
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    "2025",
    "2026"
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   "live_record_began": "2026-09-12",
   "node_history_from": "2021-01-04",
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   "record_version": 1,
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  "auditor": {
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    "reason": "no dei:AuditorName tag on the latest annual report cover (foreign private issuers and older filings carry none)",
    "state": "not_on_record"
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   "auditor_firm_id": {
    "market": "US",
    "state": "not_on_record"
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    "market": "US",
    "state": "not_on_record"
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   "changes": []
  },
  "cmr": "us-cm-kg/NASDAQ/UPB",
  "coverage": {
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   "houses": [],
   "pages_checked": [],
   "read_by": "Perplexity sonar (search) · page read by this rail",
   "read_date": "2026-11-11",
   "since": null,
   "state": "none_found"
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     "median_cadence_gap_days": 6,
     "median_filings": 52,
     "median_latency_days": 5,
     "name": "NASDAQ"
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    "sector": {
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     "median_cadence_gap_days": 6,
     "median_filings": 63,
     "median_latency_days": 4,
     "name": "2834 Pharmaceutical Preparations"
    }
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    "corporate_news": 3,
    "directors_dealings": 26,
    "prospectus": 1,
    "regulatory_filing": 9,
    "results": 7
   },
   "cadence_median_gap_days": 20,
   "filing_days": 18,
   "filings": 49,
   "latency_days": 2,
   "latest": [
    {
     "category": "SCHEDULE 13G/A",
     "date": "2026-11-06",
     "source": "https://www.sec.gov/Archives/edgar/data/2022626/000031506626002943/xslSCHEDULE_13G_X02/primary_doc.xml",
     "title": "SCHEDULE 13G/A",
     "type": "regulatory_filing"
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    {
     "category": "SCHEDULE 13G/A",
     "date": "2026-10-29",
     "source": "https://www.sec.gov/Archives/edgar/data/2022626/000183415026000006/xslSCHEDULE_13G_X02/primary_doc.xml",
     "title": "SCHEDULE 13G/A",
     "type": "regulatory_filing"
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    {
     "category": "4",
     "date": "2026-09-17",
     "source": "https://www.sec.gov/Archives/edgar/data/2022626/000119312526394330/xslF345X06/ownership.xml",
     "title": "4 — 4",
     "type": "directors_dealings"
    },
    {
     "category": "4",
     "date": "2026-09-17",
     "source": "https://www.sec.gov/Archives/edgar/data/2022626/000119312526394325/xslF345X06/ownership.xml",
     "title": "4 — 4",
     "type": "directors_dealings"
    },
    {
     "category": "4",
     "date": "2026-09-17",
     "source": "https://www.sec.gov/Archives/edgar/data/2022626/000119312526394324/xslF345X06/ownership.xml",
     "title": "4 — 4",
     "type": "directors_dealings"
    }
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   "latest_filing_date": "2026-11-06",
   "read": "the node's event lines (list_events_since), as get_filings serves them",
   "source": "https://mcp.us-cm-kg.ai/events/NASDAQ/UPB",
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    "to": "2026-11-08"
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    "read_date": "2026-11-08",
    "read_date_basis": "the record version as_of",
    "source": "https://www.sec.gov/files/company_tickers_exchange.json",
    "state": "sourced",
    "value": "NASDAQ"
   },
   "isin": {
    "read_by": "SEC Fails-to-Deliver data (CUSIP for the symbol) · ISIN = US + CUSIP + ISO 6166 check digit",
    "read_date": "2026-10-13",
    "read_date_basis": "last_seen",
    "source": "https://www.sec.gov/data-research/sec-markets-data/fails-deliver-data",
    "state": "sourced",
    "value": "US91678A1079"
   },
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    "read_by": "EDGAR submissions API (issuer header as filed) (stateOfIncorporation)",
    "read_date": "2026-11-08",
    "read_date_basis": "the record version as_of",
    "source": "https://data.sec.gov/submissions/CIK0002022626.json",
    "state": "sourced",
    "value": "United States — Delaware"
   },
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    "reason": "no GLEIF record with the exact legal name in jurisdiction US-DE",
    "state": "not_on_record"
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   "name": {
    "read_by": "EDGAR submissions API (issuer header as filed)",
    "read_date": "2026-11-08",
    "read_date_basis": "the record version as_of",
    "source": "https://data.sec.gov/submissions/CIK0002022626.json",
    "state": "sourced",
    "value": "Upstream Bio, Inc."
   },
   "sector": {
    "read_by": "EDGAR submissions API (issuer header as filed) (SIC code as assigned by the SEC)",
    "read_date": "2026-11-08",
    "read_date_basis": "the record version as_of",
    "source": "https://data.sec.gov/submissions/CIK0002022626.json",
    "state": "sourced",
    "value": "2834 Pharmaceutical Preparations"
   },
   "security_type": {
    "read_by": "EDGAR submissions API (issuer header as filed)",
    "read_date": "2026-11-08",
    "read_date_basis": "the record version as_of",
    "source": "https://data.sec.gov/submissions/CIK0002022626.json",
    "state": "sourced",
    "value": "Corporate"
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    "state": "not_on_record"
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   "ticker": {
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    "read_date": "2026-11-08",
    "read_date_basis": "the record version as_of",
    "source": "https://www.sec.gov/files/company_tickers_exchange.json",
    "state": "sourced",
    "value": "UPB"
   },
   "website": {
    "market": "US",
    "state": "not_on_record"
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  "licensed": {
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    "entitlement",
    "title",
    "date",
    "source"
   ],
   "rows": [],
   "rule": "A licensed row is served only to an agent whose firm holds that licence (licensor, entitlement). No licensed row is loaded."
  },
  "lifecycle": {
   "delisting": [],
   "domicile_change": {
    "market": "US",
    "reason": "EDGAR states no dated change of state of incorporation on a filing line",
    "state": "not_on_record"
   },
   "listing": [],
   "name_change": [],
   "segment_move": {
    "market": "US",
    "reason": "the exchanges' tier transfers are not EDGAR filings",
    "state": "not_on_record"
   }
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  "market": "US",
  "node": "us-cm-kg",
  "numbers_hash": "sha256:117aba39bae02f5ba120b413111574af78bc6f368e790a8ff439c6c3c2c659bd",
  "open_research": {
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   "rows": [],
   "state": "none_found"
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  "orderability": {
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   "client_categories": [],
   "determinable": false,
   "read": {
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    "door": "https://mcp.us-cm-kg.ai/mcp",
    "tool": "get_orderability"
   },
   "reason": "the chapter's orderability section carries no client_categories: the outcome cannot name its client category",
   "rule_version": "acm-68000/us/reasonable-basis-suitability-finra-rule-2111/r1",
   "section": "us.aio.v8"
  },
  "record": {
   "as_of": "2026-11-08",
   "url": "https://mcp.us-cm-kg.ai/record/NASDAQ/UPB",
   "version": 1
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  "schema": "research-numbers v0.1 (USR-01, 2026-11-11)",
  "status": {
   "read_date": "2026-11-08",
   "source": "https://www.nasdaqtrader.com/rss.aspx?feed=tradehalts",
   "value": "listed, not halted"
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 },
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 "path": "/us/NASDAQ/UPB",
 "schema": "research-page v0.1 (USR-02, 2026-11-11)",
 "sections": [
  {
   "id": "identity",
   "text": "The issuer is Upstream Bio, Inc., listed on NASDAQ under ticker UPB, with ISIN US91678A1079; its LEI is not on the record, which holds no GLEIF record with the exact legal name in jurisdiction US-DE. Its security type is Corporate, its segment is not on the record, its sector is 2834 Pharmaceutical Preparations, and its jurisdiction is United States, Delaware. The issuer is listed and not halted.",
   "title": "Identity and listing"
  },
  {
   "id": "disclosure",
   "text": "The record holds 49 filings in the window 2025-11-08 to 2026-11-08, across 18 filing days. Of these, 26 are directors' dealings, 9 are regulatory filings, 7 are results, 3 are AGM/EGM notices, 3 are corporate news, and 1 is a prospectus. The median gap between filing days is 20 days. The latest filing is dated 2026-11-06 and is a regulatory filing, 2 days before the record date of 2026-11-08. On NASDAQ the median cadence gap is 6.0 days, the median filings count is 52, and the median latency is 5.0 days, across 4359 issuers. In the sector 2834 Pharmaceutical Preparations, the median cadence gap is 6.0 days, the median filings count is 63.0, and the median latency is 4.0 days, across 526 issuers.",
   "title": "The disclosure read"
  },
  {
   "id": "auditor",
   "text": "The auditor of record is not on the record, which carries no dei:AuditorName tag on the latest annual report cover; the auditor's location is not on the record. The record holds no auditor changes.",
   "title": "Auditor"
  },
  {
   "id": "events",
   "text": "The record holds no listing, delisting or name change lines. The domicile change is not on the record, as EDGAR states no dated change of state of incorporation on a filing line. The segment move is not on the record, as the exchanges' tier transfers are not EDGAR filings. The halt flag is listed, not halted.",
   "title": "Events and halts"
  },
  {
   "id": "orderability",
   "text": "The outcome is not determinable, because the chapter's orderability section carries no client categories and so the outcome cannot name its client category. The rule version is acm-68000/us/reasonable-basis-suitability-finra-rule-2111/r1, and the chapter is as of 2026-11-04.",
   "title": "Orderability"
  },
  {
   "id": "coverage",
   "text": "No research houses were found on the issuer's own investor-relations page; the count is 0.",
   "title": "Coverage"
  },
  {
   "id": "open_research",
   "text": "No openly published research notes were found on the record; the count is 0.",
   "title": "Open research"
  },
  {
   "id": "licensed",
   "text": "Licensed research: none loaded. A licensed row is served only to an agent whose firm holds that licence (licensor, entitlement). No licensed row is loaded.",
   "title": "Licensed"
  },
  {
   "id": "depth",
   "text": "The issuer's years sealed are 2024, 2025 and 2026. The market's earliest sealed date is 2021-01-04. The live record began on 2026-09-12.",
   "title": "As-of depth"
  },
  {
   "id": "sources",
   "text": "7 source pages are named on this page; every value above carries its own source page and read date in the numbers.",
   "title": "Sources"
  }
 ],
 "sources": [
  {
   "for": "identity.exchange",
   "source": "https://www.sec.gov/files/company_tickers_exchange.json"
  },
  {
   "for": "identity.isin",
   "source": "https://www.sec.gov/data-research/sec-markets-data/fails-deliver-data"
  },
  {
   "for": "identity.jurisdiction",
   "source": "https://data.sec.gov/submissions/CIK0002022626.json"
  },
  {
   "for": "the disclosure lines",
   "source": "https://mcp.us-cm-kg.ai/events/NASDAQ/UPB"
  },
  {
   "for": "the halt flag",
   "source": "https://www.nasdaqtrader.com/rss.aspx?feed=tradehalts"
  },
  {
   "for": "the orderability chapter",
   "source": "https://mcp.us-cm-kg.ai/book/aio.json"
  },
  {
   "for": "the record",
   "source": "https://mcp.us-cm-kg.ai/record/NASDAQ/UPB"
  }
 ],
 "title": "Upstream Bio, Inc. (UPB) — research page",
 "writer": {
  "by": "Claude through the platform account, Haiku class; one pass; checked against the numbers",
  "engine": "claude-haiku-5-5"
 }
}